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Latest Article

Published on November 05, 2015 by Hiroki Toyoda Editorial

Oral health is a critical component of general health. If the knowledge of oral health is lacking, the quality of life decreases not only in adults but also in children. For most of junior and senior high school students, it is likely that the “oral care” is difficult to understand. When the students visit dental office for treatment of their teeth, they cannot easily understand the contents of dental treatment and the importance of oral care. more

Published on December 15, 2015 by Renee Hayslett Case Report

The pathology of major depressive disorder (MDD) involves many physiological systems, including the estrogen system, the acetylcholine system and the hypothalamus-pituitary-adrenal axis (HPA-axis). This review explores the influence of these three systems on mood and memory with emphasis on involvement of the hippocampus. Behavioral and physiological symptoms of MDD, including cognitive and mood impairments, can be mitigated or exacerbated by estrogenic activity, as well as by modulations of the acetylcholine system. In addition, HPA-axis dysregulation is thought to contribute to the hippocampus-mediated cognitive impairments characteristic of MDD. more

Published on November 5, 2015 by Susan LaTuga Case Report

In premature infants, breast milk feedings are associated with a decreased risk of necrotizing enterocolitis, sepsis, and improved neuro-cognitive development. Despite these benefits, not all premature infants receive exclusive breast milk feedings. The Hill and Humenick (H&H) scale has been used to assess maternal confidence and commitment to breastfeeding in term infants. Our goal was to test the validity of a modified H&H scale in premature infants. We examined the effect of maternal postnatal attitudes about providing breast milk using a modified H&H scale to see if maternal attitude affects the amount of breast milk fed to infants. more

Published on November 18, 2015 by Janet Lioy Case Report

We report two cases of Herpes Simplex Virus (HSV) induced hemophagocytic lymphohistiocytosis (HLH). These cases highlight that neonates with HSV may have concurrent secondary HLH, a life threatening condition in which prompt diagnosis and treatment can drastically improve survival. Therefore, a low index of suspicion is needed to send, cost effective, sensitive screening blood tests for HLH in critically ill neonates with viral infections. Ferritin is especially useful as a diagnostic tool. more

Published on November 05, 2015 by Robert Thomas Research

Men with low-risk prostate cancer are often offered active surveillance (AS), sparing them the toxicities of radical therapies and providing them with the opportunity to embark on healthy lifestyle and nutritional strategies. Annual magnetic resonance imaging (MRI) is increasingly being used to help monitor disease progress although its precise role has not been fully established. Hitherto no study has correlated changes in MRI disease status with Prostate Specific Antigen (PSA) dynamics among men managed with AS. more

Published on December 09, 2015 by Quan-guang Zhang Review

Hypoxic-ischemia (HI) causes severe brain injury in neonates. It’s one of the leading causes to neonatal death and pediatric disability, resulting in devastating consequences, emotionally and economically, to their families. A series of events happens in this process, e.g. excitatory transmitter release, extracelluar Ca2+ influxing, mitochondrial dysfunction, energy failure, and neuron death. more

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